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The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible

Symptoms persisting beyond 72 hours of appropriate antibiotic therapy warrant imaging studies like CT urography to rule out obstruction, abscesses, or structural abnormalities

It means that anyone using it should understand they are in largely uncharted territory and proceed with appropriate caution and monitoring

Hypophagia and body weight loss by tirzepatide are accompanied by fewer GI adverse events compared to semaglutide in preclinical models